Description

Insulin, Octadeutero-Phe(B1)-Octadeutero-Val(B2)- CAS NO 153700-02-8 is a specifically deuterated analog of human insulin, where phenylalanine at position B1 and valine at position B2 are replaced with their fully deuterated counterparts. This compound is of critical importance for advanced research in metabolism and pharmacokinetics, serving as a stable isotope-labeled internal standard for precise mass spectrometry-based quantification. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and CROs (Contract Research Organizations) focused on diabetes research, drug metabolism studies (DMPK), and the development of novel bioanalytical assays.

Application

• Mass Spectrometry Internal Standard: Used as a stable isotope-labeled reference standard for the accurate quantification of endogenous insulin in biological matrices via LC-MS/MS.
• Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies: Enables precise tracking of exogenous insulin analogs in preclinical and clinical research to study absorption, distribution, metabolism, and excretion.
• Proteomics and Metabolomics Research: Facilitates targeted protein analysis in complex samples, aiding in the study of insulin signaling pathways and metabolic disorders.
• Method Development and Validation: Essential for developing and validating robust, GLP-compliant bioanalytical methods for insulin and related peptides.
• Diabetes and Endocrinology Research: Supports fundamental research into insulin's structure, function, receptor interaction, and the pathophysiology of diabetes.
• Quality Control in Biopharmaceuticals: Can be employed as a system suitability standard in the quality control of therapeutic insulin products.

Basic Information

Product Name	Insulin, Octadeutero-Phe(B1)-Octadeutero-Val(B2)- CAS NO 153700-02-8
CAS No.	153700-02-8
Molecular Formula	C254H369D8N65O75S6
Molecular Weight	~5807.6 g/mol
Synonyms	Deuterated Insulin (Phe(B1)-d8, Val(B2)-d8); [d8-PheB1, d8-ValB2]-Insulin; Human Insulin (PheB1-d8, ValB2-d8); Stable Isotope-Labeled Insulin; Insulin (d8-Phe1, d8-Val2); Insulin-13C,15N (alternative labeling); Insulin Internal Standard; Isotopically Labeled Insulin Analog
EINECS	Contact for details

Quality Control

Our deuterated insulin is produced and handled under strict quality protocols to ensure the highest isotopic purity and chemical integrity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters. We adhere to relevant standards for high-purity biochemicals, ensuring product consistency and reliability for critical analytical work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot into single-use vials to minimize freeze-thaw cycles and maintain stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to standard
Purity (HPLC)	≥ 95%
Isotopic Purity (MS)	≥ 98 atom % D
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity	Assessed via receptor binding assay (Data on COA)
Solubility	Soluble in dilute acetic acid or HCl (pH 2-3)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.