Description

Boc-Val-Oh-2,3,4,4,4,5,5,5-D8 is a deuterium-labeled derivative of Boc-protected L-valine, a crucial building block in advanced organic synthesis and proteomics research. This high-purity, isotopically enriched compound is essential for creating internal standards in mass spectrometry, enabling precise quantification and metabolic pathway tracing in complex biological systems. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and CROs specializing in drug discovery, biomarker analysis, and peptide chemistry.

Application

• Mass Spectrometry Internal Standards: Serves as a critical, non-interfering reference standard for the accurate quantification of valine and valine-containing peptides in LC-MS/MS and GC-MS analyses.
• Metabolic Flux Analysis: Used as a stable isotope-labeled tracer to study amino acid metabolism, protein turnover rates, and cellular pathways in biological systems.
• Deuterated Peptide Synthesis: Acts as a protected, labeled amino acid precursor for the solid-phase or solution-phase synthesis of deuterium-labeled peptides for structural and functional studies.
• Proteomics Research: Enables precise relative and absolute quantification (SILAC, AQUA) in high-throughput proteomic profiling and biomarker discovery.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Incorporated into labeled drug candidates or metabolites to track absorption, distribution, metabolism, and excretion (ADME) with high specificity.
• NMR Spectroscopy: Useful for simplifying complex NMR spectra in structural analysis of synthetic intermediates and biomolecules through selective deuterium substitution.

Basic Information

Product Name	Boc-Val-Oh-2,3,4,4,4,5,5,5-D8
CAS No.	153568-33-3
Molecular Formula	C₁₀H₁₁D₈NO₄
Molecular Weight	235.31 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-3-methyl(2,3,4,4,4,5,5,5-²H₈)butanoic acid; N-(tert-Butoxycarbonyl)-L-valine-2,3,4,4,4,5,5,5-d8; Boc-L-valine-d8; Boc-Val-OH-d8; N-Boc-L-valine-d8; tert-Butyloxycarbonyl-L-valine-d8; (S)-2-((tert-Butoxycarbonyl)amino)-3-methylbutanoic-2,3,4,4,4,5,5,5-d8 acid; Deuterated Boc-Valine
EINECS	Contact for details

Quality Control

Every batch of Boc-Val-Oh-2,3,4,4,4,5,5,5-D8 is manufactured and tested under strict quality management systems to ensure exceptional isotopic and chemical purity for research applications. Our products undergo rigorous analytical testing, including NMR, HPLC, and MS, to confirm identity, chemical purity, isotopic enrichment, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, chiral purity, deuterium incorporation, and residual solvents is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.