Description

Diclofenac-D4 CAS NO 153466-65-0 is a deuterium-labeled analog of the widely used non-steroidal anti-inflammatory drug (NSAID) Diclofenac. This stable isotope-labeled compound is an essential reference standard and internal standard for precise quantitative analysis in bioanalytical and pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and mass spectrometry-based assays.

Application

• Internal Standard for LC-MS/MS: Critical for accurate quantification of Diclofenac in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic & Bioavailability Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical research.
• Metabolite Identification & Profiling: Serves as a tracer to identify and characterize Diclofenac metabolites using high-resolution mass spectrometry.
• Method Development & Validation: A key component in developing and validating robust, GLP-compliant analytical methods for regulatory submissions.
• Doping Control & Forensic Analysis: Used as a reference material in sports anti-doping and forensic toxicology laboratories to detect Diclofenac misuse.
• Quality Control in Pharmaceutical Manufacturing: Acts as a standard for ensuring the purity and consistency of Diclofenac active pharmaceutical ingredient (API) and finished dosage forms.

Basic Information

Product Name	Diclofenac-D4
CAS No.	153466-65-0
Molecular Formula	C14H7D4Cl2NO2
Molecular Weight	302.16 g/mol
Synonyms	2-[(2,6-Dichlorophenyl)amino]benzeneacetic-3,4,5,6-d4 acid; Diclofenac-d4; [2,3,4,5,6-2H4]Diclofenac; Deuterated Diclofenac; Diclofenac (phenyl-d4); Voltaren-d4; D4-Diclofenac; 2-(2,6-Dichloroanilino)phenylacetic-d4 Acid
EINECS	Contact for details

Quality Control

Our Diclofenac-D4 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment, chemical purity, and identity confirmation via advanced spectroscopic techniques. We support compliance with GMP/GLP guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (Chemical Purity)
Isotopic Purity (NMR/MS)	≥98.0 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.