Description

Trimethyl(4-Chloro-2-Fluorophenyl)Silane 96%, also known as 5-Chloro-2-(Trimethylsilyl)Fluorobenzene, is a high-purity organosilicon intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a versatile building block for introducing the (4-chloro-2-fluorophenyl)silane moiety into complex molecular architectures. This compound is primarily needed by research and development laboratories and production facilities in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated aryl silane functional groups.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the chlorinated and fluorinated phenyl ring system is critical for bioactivity.
• Material Science Precursor: Serves as a starting material for the development of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Cross-Coupling Reactions: Acts as a reagent in palladium-catalyzed cross-coupling reactions, such as the Hiyama coupling, for carbon-carbon bond formation.
• Organic Synthesis Building Block: Employed in medicinal chemistry and process chemistry for the protection of hydroxyl groups or as a masked phenol equivalent in multi-step syntheses.
• Chemical Research & Development: Essential for academic and industrial R&D focused on organosilicon chemistry and the exploration of new synthetic methodologies.

Basic Information

Product Name	Trimethyl(4-Chloro-2-Fluorophenyl)Silane 96%
CAS No.	153357-87-0
Molecular Formula	C9H12ClFSi
Molecular Weight	202.73 g/mol
Synonyms	5-Chloro-2-(trimethylsilyl)fluorobenzene; 4-Chloro-2-fluorophenyltrimethylsilane; (4-Chloro-2-fluorophenyl)trimethylsilane; 1-Chloro-4-fluoro-2-(trimethylsilyl)benzene; Trimethyl(4-chloro-2-fluorophenyl)silane; Benzene, 1-chloro-4-fluoro-2-(trimethylsilyl)-; 2-Fluoro-4-chlorophenyltrimethylsilane; TMS-C6H3(Cl)F
EINECS	Contact for details

Quality Control

Our Trimethyl(4-Chloro-2-Fluorophenyl)Silane 96% is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency meet the specified standards. Certificates of Analysis (COA) detailing all quality parameters are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.