Description

Cilomilast CAS NO 153259-65-5 is a selective phosphodiesterase 4 (PDE4) inhibitor, representing a significant class of compounds in pharmaceutical research. Its primary value lies in its potent anti-inflammatory activity, making it a key intermediate and active pharmaceutical ingredient (API) for targeted therapeutic development. This product is essential for pharmaceutical manufacturers and research institutions focused on developing treatments for chronic inflammatory diseases such as chronic obstructive pulmonary disease (COPD) and asthma.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active component in the formulation of anti-inflammatory and immunomodulatory drugs.
• Clinical Research & Development: Critical material for preclinical and clinical studies investigating PDE4 inhibition for respiratory conditions.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Drug Intermediate Synthesis: Used as a key building block in the multi-step synthesis of more complex pharmaceutical compounds.
• Biochemical Research: Tool compound for studying PDE4 enzyme kinetics, signal transduction pathways, and inflammatory mechanisms in vitro.

Basic Information

Product Name	Cilomilast
CAS No.	153259-65-5
Molecular Formula	C20H25NO4
Molecular Weight	343.42 g/mol
Synonyms	Ariflo; SB 207499; 4-Cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexanecarboxylic Acid; cis-4-Cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexane-1-carboxylic Acid; PDE4 Inhibitor
EINECS	Contact for details

Quality Control

Our Cilomilast is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product is tested against rigorous specifications, including identity, purity, and impurity profiles, using advanced analytical techniques such as HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all test results and confirming compliance with agreed specifications. We support development and commercial needs with material suitable for research use and GMP-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.