Description

Isoquinoline, 1,2,3,4-Tetrahydro-1-(1-Methylethyl)-, (S)- (9Ci) is a chiral, substituted tetrahydroisoquinoline derivative of significant interest in advanced organic synthesis. This compound serves as a versatile and high-value chiral building block for the construction of complex molecules with specific stereochemistry. It is primarily needed by pharmaceutical research and development organizations for the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals where stereochemical control is critical.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets and alkaloid-derived therapeutics.
• Agrochemical Research: Used in the development of novel, stereoselective pesticides and herbicides where the (S)-enantiomer imparts specific biological activity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of chiral ligands used in asymmetric hydrogenation and other catalytic transformations.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex natural products, flavors, and fragrances requiring the tetrahydroisoquinoline scaffold.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry and for exploring new reaction pathways involving chiral amines.

Basic Information

Product Name	Isoquinoline, 1,2,3,4-Tetrahydro-1-(1-Methylethyl)-, (S)- (9Ci)
CAS No.	152971-88-5
Molecular Formula	C12H17N
Molecular Weight	175.27 g/mol
Synonyms	(S)-1-Isopropyl-1,2,3,4-tetrahydroisoquinoline; (S)-1-(1-Methylethyl)-1,2,3,4-tetrahydroisoquinoline; (S)-1-Isopropyl-1,2,3,4-THIQ; (S)-1-(Propan-2-yl)-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-1-isopropylisoquinoline, (S)-; 152971-88-5; (S)-1-Isopropyl-THIQ; (S)-α-Isopropyl-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our (S)-1-Isopropyl-1,2,3,4-tetrahydroisoquinoline is produced under strict quality management systems to ensure batch-to-batch consistency and high chiral purity, which is critical for downstream synthetic applications. All batches are characterized by modern analytical techniques including chiral HPLC, GC, NMR, and MS. Certificates of Analysis (COA) detailing purity, enantiomeric excess (ee), and impurity profiles are provided with each shipment. We support custom synthesis to meet specific purity (e.g., >98%, >99%) and enantiomeric excess requirements for research and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon) to maximize stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.