Description

4-Hydroxybenzoic-2,3,5,6-D4 Acid is a deuterium-labeled isotopologue of 4-hydroxybenzoic acid, a key phenolic acid. This high-purity labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring analytical accuracy and reliability. It is primarily required by research laboratories, pharmaceutical developers, and analytical service providers engaged in metabolic studies, pharmacokinetics, and advanced material science.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of 4-hydroxybenzoic acid and related metabolites in complex biological matrices like plasma, urine, and tissue samples.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetic (DMPK) studies to track the absorption, distribution, metabolism, and excretion (ADME) of parent compounds.
• Biochemical Pathway Analysis: Facilitates the study of metabolic pathways involving phenolic acids in plants, microbes, and mammalian systems.
• Food & Beverage Analysis: Enables accurate measurement of parabens or phenolic acid content as preservatives or natural constituents.
• Environmental Monitoring: Aids in the trace analysis of phenolic pollutants and their degradation products in environmental samples.
• Stable Isotope Labeling: Serves as a building block for the synthesis of more complex deuterated molecules for research.
• Quality Control in Manufacturing: Supports analytical method development and validation in GMP/GLP environments for quality assurance.

Basic Information

Product Name	4-Hydroxybenzoic-2,3,5,6-D4 Acid
CAS No.	152404-47-2
Molecular Formula	C7D4H2O3
Molecular Weight	142.14 g/mol
Synonyms	4-Hydroxybenzoic Acid-d4; p-Hydroxybenzoic Acid-d4; Benzoic-2,3,5,6-d4 Acid, 4-Hydroxy-; Deutero-p-hydroxybenzoic Acid; 4-Hydroxy[2,3,5,6-2H4]benzoic Acid; Paraben Related Compound D4; PHBA-d4; 4-Hydroxybenzoic Acid (Ring-D4)
EINECS	Contact for details

Quality Control

Every batch of our 4-Hydroxybenzoic-2,3,5,6-D4 Acid is produced and analyzed under strict quality protocols to ensure the highest isotopic and chemical purity for sensitive analytical applications. We provide comprehensive Certificates of Analysis (COA) detailing isotopic enrichment (D atom %), chemical purity by HPLC, and identification data. Our quality systems support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D atom %)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.