Description

4-Methoxybenzoic-2,3,5,6-D4 Acid is a deuterium-labeled isotopologue of 4-methoxybenzoic acid (anisic acid), where four hydrogen atoms on the aromatic ring are replaced with deuterium. This high-purity labeled standard is critical for applications requiring precise quantification and metabolic pathway tracing, offering superior signal differentiation in analytical techniques. It is primarily utilized by research scientists and quality control laboratories in the pharmaceutical, agrochemical, and advanced material sectors for use as an internal standard in mass spectrometry, NMR spectroscopy, and pharmacokinetic studies.

Application

• Internal Standard for Quantitative Analysis: Used in LC-MS, GC-MS, and NMR for accurate quantification of anisic acid and related compounds in complex matrices.
• Metabolic Tracing & Drug Metabolism Studies: Serves as a stable, non-radioactive tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical compounds.
• Pharmaceutical Impurity Profiling: Enables the identification and measurement of process-related impurities and degradants in active pharmaceutical ingredients (APIs).
• Agrochemical Research: Applied in environmental fate studies and residue analysis of pesticides and herbicides.
• Synthesis of Labeled Compounds: Acts as a key deuterated building block for the synthesis of more complex isotopically labeled molecules for research.
• Forensic & Doping Control Analysis: Provides a reliable reference standard for confirmatory testing in forensic toxicology and anti-doping programs.

Basic Information

Product Name	4-Methoxybenzoic-2,3,5,6-D4 Acid
CAS No.	152404-46-1
Molecular Formula	C8H4D4O3
Molecular Weight	156.17 g/mol
Synonyms	2,3,5,6-Tetradeutero-4-methoxybenzoic Acid; Deuterated Anisic Acid; p-Anisic Acid-d4; 4-Methoxybenzoic Acid-d4; 4-(Methoxy-d0)benzoic-2,3,5,6-d4 Acid; Benzoic-2,3,5,6-d4 acid, 4-methoxy-; p-Methoxybenzoic-2,3,5,6-D4 Acid
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality systems to ensure high isotopic purity and chemical integrity. Each batch is characterized by NMR and mass spectrometry to confirm deuterium incorporation and chemical purity. Certificates of Analysis (COA) are provided, detailing specifications for isotopic enrichment (typically >98 atom % D), chemical purity (by HPLC), and identity confirmation. We support compliance with cGMP and ISO 9001 standards for research and quality control applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (NMR/MS)	≥98 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.