Description

n-(tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is a protected amino acid derivative, specifically a Boc-protected tetrahydroisoquinoline carboxylic acid, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the controlled construction of complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and bioactive compounds. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality building blocks for peptide mimetics and heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of drug candidates, particularly those targeting neurological and cardiovascular diseases.
• Peptidomimetics Research: Used to incorporate the rigid tetrahydroisoquinoline scaffold into peptide backbones to enhance metabolic stability and receptor selectivity.
• Combinatorial Chemistry: A valuable building block in solid-phase and solution-phase library synthesis for high-throughput screening.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides and fungicides with complex stereochemistry.
• Asymmetric Catalysis Substrate: Serves as a substrate for developing and testing new chiral catalysts and synthetic methodologies.
• Academic & R&D Laboratories: Fundamental reagent for studying heterocyclic chemistry and developing novel synthetic routes in academic and industrial R&D settings.

Basic Information

Product Name	n-(tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	151838-62-9
Molecular Formula	C15H19NO4
Molecular Weight	277.32 g/mol
Synonyms	Boc-Tic-OH; (3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, 1-(1,1-dimethylethyl) ester; tert-Butyl (3S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate; (S)-1-Boc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; Boc-(S)-Tic-OH; (S)-N-Boc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, N-(tert-butoxycarbonyl)-; (S)-N-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our n-(tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral excess, and impurity profiles is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.