Description

Apadoline CAS NO 151729-74-7 is a selective kappa opioid receptor (KOR) agonist, representing a significant compound in pharmaceutical research and development. Its primary value lies in its potential for modulating pain perception without the typical side-effect profile associated with mu opioid receptor agonists. This makes it a critical intermediate and reference standard for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on developing novel, non-addictive analgesics and central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel analgesic drugs.
• Preclinical Studies: Used in animal models to study the pharmacology, efficacy, and safety profile of kappa opioid receptor agonists.
• Biochemical Assay Development: Employed as a ligand in receptor binding assays and functional studies to screen for new compounds or understand receptor mechanisms.
• Neuroscience Research: A vital tool for investigating the role of the kappa opioid system in pain, mood, addiction, and other neurological processes.
• Chemical Synthesis: Acts as a sophisticated building block for medicinal chemists synthesizing analogs and derivatives for structure-activity relationship (SAR) studies.
• Quality Control & Analytical Testing: Used as a high-purity standard in HPLC, LC-MS, and NMR for method validation and impurity profiling in API manufacturing.

Basic Information

Item	Detail
Product Name	Apadoline
CAS No.	151729-74-7
Molecular Formula	C24H26N2O3
Molecular Weight	390.48 g/mol
Synonyms	(-)-Apadoline; (3R)-3-[(1S)-1-Cyclohexylethyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]-3-benzazepin-2-one; U-62066E; Spiradoline mesylate analog; Kappa opioid receptor agonist U-62066; 1,3,4,5-Tetrahydro-7,8-dimethoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]-3-[(1S)-1-cyclohexylethyl]-3-benzazepin-2(3H)-one
EINECS	Contact for details

Quality Control

Our Apadoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.