Description

Dl-5-Methyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid CAS NO 151637-59-1 is a high-purity, non-natural amino acid derivative belonging to the tetrahydroisoquinoline class, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, constrained scaffold that is essential for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly for central nervous system (CNS) targets, as well as by fine chemical manufacturers producing specialized intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of potential drug candidates, especially in neurology and psychiatry.
• Peptidomimetics: Used to incorporate constrained amino acid motifs into peptide analogs to enhance metabolic stability and receptor selectivity.
• Chemical Biology Probes: Serves as a building block for creating tool compounds to study enzyme function and protein-protein interactions.
• Asymmetric Synthesis: Employed as a starting material or resolving agent in catalytic asymmetric transformations to access enantiomerically pure compounds.
• Academic & Industrial R&D: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Fine Chemical Production: An intermediate in the multi-step synthesis of complex, high-value specialty chemicals.

Basic Information

Product Name	Dl-5-Methyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	151637-59-1
Molecular Formula	C11H13NO2
Molecular Weight	191.23 g/mol
Synonyms	DL-5-Methyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; (±)-5-Methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; 5-Methyl-3,4-dihydro-1H-isoquinoline-3-carboxylic acid (racemic); 5-Methyl-Tic; Racemic 5-methyl-TIQ-3-COOH; DL-5-Me-Tic; 151637-59-1
EINECS	Contact for details

Quality Control

Our Dl-5-Methyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Racemic mixture (DL)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.