Description

(1R,4S)-Rel-4-Amino-1,2,3,4-tetrahydro-3-oxo-1-isoquinolinecarboxylic acid hydrobromide is a high-purity, chiral organic salt of significant interest in advanced pharmaceutical synthesis. This compound serves as a critical building block for the development of novel active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular pathways. It is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical and fine chemical industries who require reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, particularly for central nervous system (CNS) and cardiovascular applications.
• Asymmetric Synthesis: Utilized as a building block in stereoselective synthesis to introduce the (1R,4S)-tetrahydroisoquinoline scaffold into target molecules.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs for new therapeutic agents.
• Process Development: Serves as a starting material or intermediate in the scale-up and optimization of API manufacturing processes under GMP conditions.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Peptidomimetic Chemistry: The amino acid-like structure makes it valuable for designing and synthesizing peptide analogs and enzyme inhibitors.

Basic Information

Product Name	(1R,4S)-Rel-4-Amino-1,2,3,4-tetrahydro-3-oxo-1-isoquinolinecarboxylic acid hydrobromide
CAS No.	151312-48-0
Molecular Formula	C11H11N2O3·HBr
Molecular Weight	299.13 g/mol
Synonyms	(1R,4S)-4-Amino-1,2,3,4-tetrahydro-3-oxo-1-isoquinolinecarboxylic acid HBr; (1R,4S)-4-Amino-3,4-dihydro-3-oxo-1(2H)-isoquinolinecarboxylic acid hydrobromide; Rel-(1R,4S)-4-Amino-1,2,3,4-tetrahydro-3-oxo-1-isoquinolinecarboxylic acid hydrobromide; 4-Amino-1,2,3,4-tetrahydro-3-oxo-1-isoquinolinecarboxylic acid hydrobromide (rel-(1R,4S)-); 1-Isoquinolinecarboxylic acid, 4-amino-1,2,3,4-tetrahydro-3-oxo-, hydrobromide, (1R,4S)-rel-; (1R,4S)-rel-4-Amino-1,2,3,4-tetrahydro-3-oxo-1-isoquinolinecarboxylic acid, hydrobromide
EINECS	Contact for details

Quality Control

Our (1R,4S)-Rel-4-Amino-1,2,3,4-tetrahydro-3-oxo-1-isoquinolinecarboxylic acid hydrobromide is produced under a strict quality management system to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. All materials are subjected to rigorous analytical testing, including chiral purity verification. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.