Description

tert-Butyl 4-(5-Nitro-1H-Indol-3-Yl)-5,6-Dihydropyridine-1(2H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its unique indole-dihydropyridine hybrid structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutic agents, including kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially those targeting specific enzymes or receptors.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: Serves as a core structural component in the design and synthesis of potential kinase inhibitors due to its privileged heterocyclic architecture.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing high-value, complex organic molecules for clinical trials.
• Biochemical Tool Compound: May be utilized in the development of chemical probes for investigating biological pathways and target validation.

Basic Information

Product Name	tert-Butyl 4-(5-Nitro-1H-Indol-3-Yl)-5,6-Dihydropyridine-1(2H)-Carboxylate
CAS No.	151273-41-5
Molecular Formula	C18H21N3O4
Molecular Weight	343.38 g/mol
Synonyms	1-Boc-4-(5-nitro-1H-indol-3-yl)-1,2,3,6-tetrahydropyridine; tert-Butyl 4-(5-nitro-1H-indol-3-yl)-3,6-dihydro-2H-pyridine-1-carboxylate; 4-(5-Nitro-1H-indol-3-yl)-1,2,3,6-tetrahydropyridine-1-carboxylic acid tert-butyl ester; 1,2,3,6-Tetrahydro-4-(5-nitro-1H-indol-3-yl)pyridine-1-carboxylic acid tert-butyl ester; 1-N-Boc-4-(5-nitroindol-3-yl)-1,2,3,6-tetrahydropyridine; 151273-41-5; 4-(5-Nitro-1H-indol-3-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(5-Nitro-1H-Indol-3-Yl)-5,6-Dihydropyridine-1(2H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.