Description

1,2(1H)-Isoquinolinedicarboxylic Acid, 3,4-Dihydro-, 2-(1,1-Dimethylethyl) Ester, (1R)- is a high-purity, chiral isoquinoline derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated building block and key chiral intermediate for the development of complex, biologically active molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Agrochemical Synthesis: Used as a building block for creating novel, enantiomerically pure pesticides and herbicides with improved efficacy and environmental profiles.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing specialized ligands used in chiral catalysis to induce stereoselectivity in reactions.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals for research and industrial applications.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	1,2(1H)-Isoquinolinedicarboxylic Acid, 3,4-Dihydro-, 2-(1,1-Dimethylethyl) Ester, (1R)-
CAS No.	151004-96-5
Molecular Formula	C16H19NO4
Molecular Weight	289.33 g/mol
Synonyms	(1R)-2-(tert-Butyl) 1-methyl 3,4-dihydro-1H-isoquinoline-1,2-dicarboxylate; (R)-2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid methyl ester; (R)-1,2,3,4-Tetrahydro-2-[(1,1-dimethylethoxy)carbonyl]-1-isoquinolinecarboxylic acid methyl ester; (R)-N-Boc-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid methyl ester; (R)-Methyl 2-((tert-butoxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylate; (R)-1-Carbomethoxy-N-Boc-1,2,3,4-tetrahydroisoquinoline; Chiral Isoquinoline Ester; (R)-Boc-Tic-OMe
EINECS	Contact for details

Quality Control

Our 1,2(1H)-Isoquinolinedicarboxylic Acid, 3,4-Dihydro-, 2-(1,1-Dimethylethyl) Ester, (1R)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.