Description

(S)-2-Boc-3,4-Dihydro-1H-Isoquinoline-1-Carboxylic Acid CAS NO 151004-94-3 is a high-purity, chiral building block essential for advanced pharmaceutical synthesis. This compound serves as a critical intermediate in the development of active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular diseases. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in asymmetric synthesis and peptidomimetic drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, especially in medicinal chemistry programs.
• Peptidomimetics Research: Used to construct constrained peptide analogs and protease inhibitors due to its isoquinoline scaffold.
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce the (S)-configuration into target molecules.
• API Development: Integral in the multi-step synthesis of potential therapeutics for central nervous system (CNS) disorders.
• Chemical Biology Probes: Serves as a precursor for labeled compounds used in mechanism-of-action studies.
• Custom Synthesis: A starting material for contract research organizations (CROs) offering bespoke chemical services.

Basic Information

Product Name	(S)-2-Boc-3,4-Dihydro-1H-Isoquinoline-1-Carboxylic Acid
CAS No.	151004-94-3
Molecular Formula	C₁₅H₁₉NO₄
Molecular Weight	277.32 g/mol
Synonyms	(S)-1-[(tert-Butoxycarbonyl)amino]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (S)-2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (S)-2-Boc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (S)-2-(Boc-amino)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; (S)-3-Carboxy-1,2,3,4-tetrahydroisoquinoline-2-N-Boc; BOC-D-Tic-OH (common abbreviation); (S)-Boc-Tic-OH; (S)-2-(tert-Butyloxycarbonyl)-3,4-dihydro-1H-isoquinoline-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our (S)-2-Boc-3,4-Dihydro-1H-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate production. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.