Description

(R)-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid CAS NO 151004-93-2 is a high-purity chiral building block of significant importance in modern synthetic chemistry. This compound serves as a critical intermediate for the development of enantiomerically pure pharmaceuticals and bioactive molecules. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for applications in asymmetric synthesis and drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Asymmetric Synthesis: Used as a precursor for chiral catalysts, ligands (e.g., for transition metal catalysis), and auxiliaries to induce stereoselectivity in organic reactions.
• Peptidomimetics Research: Incorporated into peptide backbones to create conformationally constrained analogs with enhanced metabolic stability and biological activity.
• Agrochemical Development: Serves as a building block for novel, enantiopure herbicides, fungicides, and plant growth regulators.
• Academic & R&D: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and the discovery of new therapeutic agents.
• Fine Chemical Production: Employed in the custom synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	(R)-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid
CAS No.	151004-93-2
Molecular Formula	C10H11NO2
Molecular Weight	177.20 g/mol
Synonyms	(R)-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid; (R)-Tic-OH; (R)-1,2,3,4-Tetrahydro-1-isoquinolinecarboxylic acid; (1R)-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid; (R)-TIQ-1-COOH; D-Tic-OH; (R)-Tic; (R)-1,2,3,4-Tetrahydro-1-isoquinoline carboxylic acid
EINECS	Contact for details

Quality Control

Our (R)-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. We provide material with typical chiral purity exceeding 99% (by HPLC) and chemical purity >98%. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. Our quality commitment ensures material suitable for demanding applications in GMP and non-GMP pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	> 98.0%
Chiral Purity (HPLC)	> 99.0% ee
Loss on Drying	< 0.5%
Residue on Ignition	< 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.