Description

(S)-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is a high-value, non-proteinogenic amino acid derivative and a key chiral building block in organic synthesis. Its enantiopure (S)-configuration is critical for imparting specific biological activity and stereochemical integrity in advanced pharmaceutical intermediates. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-purity chiral synthons.

Application

• Pharmaceutical Intermediate: A crucial chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) drugs, enzyme inhibitors, and receptor modulators.
• Peptidomimetics & Drug Design: Used to incorporate the rigid, aromatic tetrahydroisoquinoline scaffold into peptide backbones, enhancing metabolic stability and binding affinity in novel therapeutic candidates.
• Asymmetric Catalysis & Ligand Synthesis: Serves as a starting material for the preparation of chiral ligands and organocatalysts used in enantioselective transformations.
• Agrochemical Research: Employed in the development of novel, stereospecific herbicides, fungicides, and plant growth regulators.
• Academic & R&D Laboratories: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry research programs.
• Fine Chemical Synthesis: Used in the multi-step synthesis of complex natural products and other specialty chemicals requiring the tetrahydroisoquinoline motif.

Basic Information

Product Name	(S)-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid
CAS No.	151004-92-1
Molecular Formula	C10H11NO2
Molecular Weight	177.20 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid; (S)-Tic-OH; (S)-1,2,3,4-Tetrahydro-1-isoquinolinecarboxylic acid; (S)-TIC; L-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid; (S)-1,2,3,4-Tetrahydro-2-isoquinolinecarboxylic acid; (S)-THIQ-1-COOH; (S)-1-Carboxytetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our (S)-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment. We support compliance with cGMP, ICH guidelines, and relevant pharmacopeial standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.