Description

(R)-n-Cbz-3,4-Dihydro-1H-Isoquinolinecarboxylic Acid CAS NO 151004-88-5 is a high-purity, enantiomerically pure chiral building block essential for advanced organic synthesis. This compound serves as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals, where stereochemical integrity is paramount. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of potential drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Asymmetric Synthesis: Used as a versatile building block in stereoselective reactions to introduce the (R)-configured isoquinoline scaffold into target molecules.
• Peptidomimetics & Bioactive Molecule Development: Employed in the synthesis of constrained peptide analogs and other bioactive compounds that mimic natural peptide structures.
• Catalyst & Ligand Synthesis: Serves as a precursor for the development of novel chiral catalysts and ligands used in homogeneous catalysis.
• Agrochemical Research: Utilized in the discovery and synthesis of new chiral pesticides and herbicides with enhanced efficacy and selectivity.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	(R)-n-Cbz-3,4-Dihydro-1H-Isoquinolinecarboxylic Acid
CAS No.	151004-88-5
Molecular Formula	C18H17NO4
Molecular Weight	311.33 g/mol
Synonyms	(R)-1-[(Benzyloxy)carbonyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid; (R)-N-Carbobenzyloxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid; (R)-N-Cbz-Tic-OH; (R)-N-Cbz-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid; (R)-3-Carboxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid Benzyl Ester; (R)-CBZ-TIC-OH; (R)-1-CBZ-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our (R)-n-Cbz-3,4-Dihydro-1H-Isoquinolinecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard spectroscopic methods for identity confirmation, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.