Description

Retigabine Dihydrochloride is a high-purity pharmaceutical active ingredient and research chemical. This compound is a potassium channel opener primarily valued for its neurological research applications and as a key intermediate in pharmaceutical development. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on central nervous system (CNS) therapeutics. The product is supplied under stringent quality control to ensure reliability for critical R&D and production processes.

Application

• Pharmaceutical Active Ingredient (API): Serves as the active component in the formulation of finished dosage forms for neurological indications.
• Neurological Research: A critical tool for in vitro and in vivo studies targeting potassium channels and neuronal excitability.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing via HPLC, LC-MS, or NMR.
• Preclinical Development: Employed in pharmacokinetic, pharmacodynamic, and toxicology studies during drug discovery pipelines.
• Chemical Synthesis Intermediate: Acts as a key building block for the synthesis of more complex derivatives or related chemical entities.
• Academic Research: Utilized in university and institutional labs for fundamental neuroscience and pharmacology research projects.

Basic Information

Product Name	Retigabine Dihydrochloride
CAS No.	150812-13-8
Molecular Formula	C16H18FN3O2 • 2HCl
Molecular Weight	392.25 g/mol (for dihydrochloride salt)
Synonyms	Ezogabine Dihydrochloride; N-(2-Amino-4-(4-fluorobenzylamino)-phenyl)carbamic acid ethyl ester dihydrochloride; D-23129; Trobalt; Potiga; Ethyl N-[2-amino-4-[(4-fluorophenyl)methylamino]phenyl]carbamate dihydrochloride; Retigabine HCl
EINECS	Contact for details

Quality Control

Our Retigabine Dihydrochloride is manufactured and tested to meet high-purity standards suitable for pharmaceutical research and development. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling. A Certificate of Analysis (COA) detailing all test results is provided to ensure full traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.