Description

Dimethyl-(2S, 3Ar, 8As)-8-Phenylsulfonyl-5-Phenylsulfonyloxy-1,2,3,3A,8A-Hexahydropyrrolo[2,3]Indol-1,2-Dicarboxylate is a high-purity, complex heterocyclic compound featuring a fused pyrroloindole core with multiple sulfonyl functional groups. This compound serves as a critical advanced intermediate in the synthesis of complex pharmaceutical molecules, particularly those targeting central nervous system disorders. It is primarily required by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex, biologically active molecules, especially for neurological and psychiatric drug candidates.
• Organic Synthesis Research: Used in academic and industrial research to explore novel chemical transformations and construct complex molecular architectures.
• Process Chemistry Development: Serves as a reference standard or starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis: Utilized in stereoselective synthesis due to its defined chiral centers (2S, 3Ar, 8As), enabling the production of enantiomerically pure final products.
• Medicinal Chemistry: Core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of drug leads.

Basic Information

Product Name	Dimethyl-(2S, 3Ar, 8As)-8-Phenylsulfonyl-5-Phenylsulfonyloxy-1,2,3,3A,8A-Hexahydropyrrolo[2,3]Indol-1,2-Dicarboxylate
CAS No.	150804-39-0
Molecular Formula	C27H25NO8S2
Molecular Weight	555.62 g/mol
Synonyms	Dimethyl 8-phenylsulfonyl-5-(phenylsulfonyloxy)-1,2,3,3a,8a-hexahydropyrrolo[2,3-b]indole-1,2-dicarboxylate; (2S,3aR,8aS)-Dimethyl 8-(benzenesulfonyl)-5-[(benzenesulfonyl)oxy]-2,3,3a,8a-tetrahydro-1H-pyrrolo[2,3-b]indole-1,2-dicarboxylate; 1H-Pyrrolo[2,3-b]indole-1,2-dicarboxylic acid, 8-(benzenesulfonyl)-5-[(benzenesulfonyl)oxy]-2,3,3a,8a-tetrahydro-, 1,2-dimethyl ester, (2S,3aR,8aS)-; CAS 150804-39-0; Pyrroloindole sulfonate intermediate; Advanced pharmaceutical intermediate 150804-39-0.
EINECS	Contact for details

Quality Control

Our Dimethyl-(2S, 3Ar, 8As)-8-Phenylsulfonyl-5-Phenylsulfonyloxy-1,2,3,3A,8A-Hexahydropyrrolo[2,3]Indol-1,2-Dicarboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding pharmaceutical research. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development with GMP-compatible documentation and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.