Description

L-Ipratropium Bromide is the pharmacologically active enantiomer of the anticholinergic bronchodilator Ipratropium Bromide. This high-purity chiral intermediate is critical for the development and manufacturing of advanced respiratory therapeutics targeting chronic obstructive pulmonary disease (COPD) and asthma. It is essential for pharmaceutical R&D laboratories and API manufacturers focused on producing enantiomerically pure, next-generation inhalable medications.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Primary use in the synthesis of enantiomerically pure L-Ipratropium Bromide or related anticholinergic drugs.
• Pharmaceutical Research & Development: A key chiral building block for medicinal chemists developing new bronchodilators with improved efficacy and reduced side-effect profiles.
• Analytical Reference Standard: Serves as a high-purity standard for HPLC, LC-MS, and other analytical methods in quality control and pharmacokinetic studies.
• Formulation Development: Used in pre-clinical and clinical trial material manufacturing for metered-dose inhalers (MDIs) and dry powder inhalers (DPIs).
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes and scaling up production for commercial pharmaceutical manufacturing.

Basic Information

Product Name	L-Ipratropium Bromide
CAS No.	150575-67-0
Molecular Formula	C20H30BrNO3
Molecular Weight	412.36 g/mol
Synonyms	(1R,3r,5S,8r)-3-[(RS)-Hydroxy(8-methyl-8-isopropyl-8-azoniabicyclo[3.2.1]oct-3-yl)acetyl]oxy-8-methyl-8-isopropyl-8-azoniabicyclo[3.2.1]octane bromide; (-)-Ipratropium Bromide; L-Form Ipratropium Bromide; (8R)-Ipratropium Bromide; Ipratropium Bromide Enantiomer; Tropate L-Ipratropium Bromide
EINECS	Contact for details

Quality Control

Our L-Ipratropium Bromide is manufactured under strict quality management systems. It undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure compliance with pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, assay, enantiomeric excess, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.