Description

D-Ipratropium Bromide is the dextrorotatory enantiomer of the anticholinergic agent Ipratropium Bromide, a key intermediate in the development of stereochemically pure pharmaceuticals. This high-purity compound is critical for research and manufacturing processes where the specific biological activity and reduced side-effect profile of a single enantiomer are required. It is primarily utilized by pharmaceutical R&D laboratories and API manufacturers focused on advanced respiratory therapeutics and other muscarinic receptor-targeting drugs.

Application

• Key chiral intermediate in the synthesis of enantiomerically pure Ipratropium Bromide API.
• Pharmacological research and development for stereoselective anticholinergic agents.
• Reference standard in analytical method development and quality control for chiral separation.
• Precursor in the study of structure-activity relationships (SAR) for muscarinic receptor antagonists.
• Process development and optimization for the manufacture of single-enantiomer pharmaceuticals.

Basic Information

Product Name	D-Ipratropium Bromide
CAS No.	150575-66-9
Molecular Formula	C20H30BrNO3
Molecular Weight	412.37 g/mol
Synonyms	(8r)-3α-Hydroxy-8-isopropyl-1αh,5αh-tropanium Bromide (±)-Tropate; (1R,3r,5S,8r)-3-[(2S)-3-Hydroxy-2-phenylpropanoyl]oxy-8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]octane Bromide; Dex-Ipratropium Bromide; (+)-Ipratropium Bromide; D-Form Ipratropium Bromide; Enantiomer of Ipratropium Bromide
EINECS	Contact for details

Quality Control

Our D-Ipratropium Bromide is manufactured under strict quality systems to ensure high enantiomeric purity and chemical integrity. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing chiral purity, chemical assay, and impurity profiles. We adhere to cGMP guidelines for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-Enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.