Description

(R)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid Amide is a high-purity chiral building block of significant importance in modern asymmetric synthesis. This compound serves as a critical intermediate for the development of novel pharmaceuticals and bioactive molecules, particularly those targeting the central nervous system. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of complex organic compounds, drug discovery, and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates, especially in neurological and psychiatric therapeutic areas.
• Asymmetric Catalysis Research: Used as a precursor or ligand in the development of new catalytic systems for enantioselective transformations.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and the construction of complex molecular scaffolds with defined stereochemistry.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Biochemical Research: May be used in the study of enzyme inhibitors or receptor ligands due to its isoquinoline core structure.

Basic Information

Product Name	(R)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid Amide
CAS No.	150448-64-9
Molecular Formula	C10H12N2O
Molecular Weight	176.22 g/mol
Synonyms	(R)-1,2,3,4-Tetrahydroisoquinoline-3-carboxamide; (3R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxamide; (R)-Tic-NH2; (R)-3-Carbamoyl-1,2,3,4-tetrahydroisoquinoline; (R)-TIQCA; (R)-Amino(1,2,3,4-tetrahydro-3-isoquinolinyl)methanone
EINECS	Contact for details

Quality Control

Our (R)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid Amide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.