Description

(R)-3-Aminomethyl-2-Boc-3,4-Dihydro-1H-Isoquinoline CAS NO 150417-18-8 is a high-purity chiral building block featuring a protected amine and a dihydroisoquinoline scaffold. This compound is critical for the synthesis of complex, biologically active molecules where stereochemical integrity is paramount. It is primarily utilized by pharmaceutical R&D and process chemistry teams in the development of new therapeutic agents, particularly in central nervous system (CNS) and oncology research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially for neurological and oncological targets.
• Asymmetric Synthesis: Used in the construction of complex, enantiomerically pure molecules for medicinal chemistry and process optimization.
• Peptidomimetics & Scaffold Development: Serves as a constrained scaffold or backbone for designing peptide mimics and small molecule libraries.
• Chemical Biology Probes: Employed in the synthesis of tool compounds for studying enzyme mechanisms and receptor interactions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for the pharmaceutical industry.
• Academic Research: Used in university and institutional labs for methodological studies in organic synthesis and catalysis.

Basic Information

Item	Detail
Product Name	(R)-3-Aminomethyl-2-Boc-3,4-Dihydro-1H-Isoquinoline
CAS No.	150417-18-8
Molecular Formula	C16H24N2O2
Molecular Weight	276.38 g/mol
Synonyms	(R)-2-(tert-Butoxycarbonyl)-3-(aminomethyl)-1,2,3,4-tetrahydroisoquinoline; (R)-3-(Aminomethyl)-2-Boc-1,2,3,4-tetrahydroisoquinoline; (R)-N-Boc-3-aminomethyl-1,2,3,4-tetrahydroisoquinoline; (R)-3-Aminomethyl-2-Boc-THIQ; (R)-2-Boc-3-aminomethyl-3,4-dihydro-1H-isoquinoline; (R)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; BOC-(R)-3-Aminomethyl-THIQ
EINECS	Contact for details

Quality Control

Our (R)-3-Aminomethyl-2-Boc-3,4-Dihydro-1H-Isoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.