Description

6-(2-(1H-Tetrazol-5-Yl)Ethyl)-1,2,3,4,4A,5,6,7,8,8A-Decahydroisoquinoline-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular scaffold that combines a tetrazole moiety with a decahydroisoquinoline core. This compound is valued for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in cardiovascular and central nervous system (CNS) therapeutic areas. It is primarily sought by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in innovative drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates targeting specific biological pathways.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization, especially for compounds requiring a tetrazole bioisostere.
• Angiotensin II Receptor Antagonist Development: The tetrazole group is a hallmark of sartan-class drugs, making this intermediate relevant for developing new antihypertensive agents.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for investigating enzyme function and receptor interactions in biological systems.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for pilot and commercial manufacturing of APIs.

Basic Information

Product Name	6-(2-(1H-Tetrazol-5-Yl)Ethyl)-1,2,3,4,4A,5,6,7,8,8A-Decahydroisoquinoline-3-Carboxylic Acid
CAS No.	150131-78-5
Molecular Formula	C₁₃H₂₁N₅O₂
Molecular Weight	279.34 g/mol
Synonyms	1,2,3,4,4a,5,6,7,8,8a-Decahydroisoquinoline-3-carboxylic acid, 6-[2-(1H-tetrazol-5-yl)ethyl]-; Decahydro-6-[2-(1H-tetrazol-5-yl)ethyl]isoquinoline-3-carboxylic acid; Tetrazole-substituted decahydroisoquinoline carboxylic acid; 150131-78-5; (3S,4aR,8aR)-6-[2-(2H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid (stereoisomer specific).
EINECS	Contact for details

Quality Control

Our 6-(2-(1H-Tetrazol-5-Yl)Ethyl)-1,2,3,4,4A,5,6,7,8,8A-Decahydroisoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.