Description

[R-(E)]-α-[3-[2-(7-Chloro-2-Quinolinyl)Ethenyl]Phenyl]-2-(1-Hydroxy-1-Methylethyl)Benzenepropanol is a high-purity, non-racemic chiral compound of significant interest in advanced pharmaceutical research and development. This molecule serves as a critical synthetic intermediate or reference standard for the development of novel therapeutic agents, particularly those targeting inflammatory pathways. It is essential for research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules. Our supply is characterized by stringent quality control, ensuring reliability for sensitive applications.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of potent leukotriene receptor antagonists and other anti-inflammatory drug candidates.
• Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical laboratories to ensure product purity and identity.
• Biochemical Research: Employed in studies investigating leukotriene biology, receptor-ligand interactions, and structure-activity relationships (SAR).
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Custom Synthesis: A foundational compound for the custom synthesis of derivatives and analogs for proprietary drug discovery programs.

Basic Information

Product Name	[R-(E)]-α-[3-[2-(7-Chloro-2-Quinolinyl)Ethenyl]Phenyl]-2-(1-Hydroxy-1-Methylethyl)Benzenepropanol
CAS No.	150026-75-8
Molecular Formula	C29H28ClNO2
Molecular Weight	458.0 g/mol
Synonyms	(R,E)-Montelukast; (R)-Montelukast; (R,E)-MK-0476; (R)-2-[1-[(1R)-1-[3-[(E)-2-(7-Chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]phenyl]-2-propanol; (1R)-1-[[(1R)-1-[3-[(E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic Acid (related acid form); R-Montelukast Free Base; (R)-Enantiomer of Montelukast Intermediate
EINECS	Contact for details

Quality Control

Our [R-(E)]-α-[3-[2-(7-Chloro-2-Quinolinyl)Ethenyl]Phenyl]-2-(1-Hydroxy-1-Methylethyl)Benzenepropanol is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure identity, potency, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications. We support development and commercial projects requiring material that meets ICH guidelines and current Good Manufacturing Practice (cGMP) standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (R,E isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.