Description

(1S,2R,8R,8Ar)-1,2,8-Triacetoxy-1,2,3,5,8,8A-Hexahydro-5-Oxyindolizine is a sophisticated, multi-functional indolizine derivative that serves as a critical chiral building block and synthetic intermediate in advanced organic synthesis. Its complex stereochemistry and reactive functional groups make it invaluable for constructing intricate molecular architectures with high precision. This compound is primarily sought by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), natural product analogs, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new therapeutic agents, particularly in alkaloid-based drug discovery.
• Asymmetric Synthesis: Utilized as a versatile scaffold in stereoselective reactions to introduce complex molecular frameworks.
• Natural Product Synthesis: Serves as a core structural unit in the total synthesis of complex natural products containing the indolizidine or related alkaloid skeletons.
• Chemical Biology Research: Used as a probe or precursor in studying biological pathways and enzyme interactions due to its specific stereochemistry.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of high-value fine chemicals.
• Academic Research: A valuable compound for methodological studies in organic chemistry, exploring new catalytic transformations and reaction mechanisms.

Basic Information

Product Name	(1S,2R,8R,8Ar)-1,2,8-Triacetoxy-1,2,3,5,8,8A-Hexahydro-5-Oxyindolizine
CAS No.	149913-46-2
Molecular Formula	C15H19NO7
Molecular Weight	325.32 g/mol
Synonyms	1,2,8-Triacetoxy-1,2,3,5,8,8a-hexahydro-5-oxoindolizine; (1S,2R,8R,8aR)-1,2,8-Triacetoxy-1,2,3,5,8,8a-hexahydro-5-oxoindolizine; 1,2,3,5,8,8a-Hexahydro-1,2,8-triacetoxy-5-oxoindolizine; Triacetylswainsonine derivative; Indolizine-5-one, 1,2,3,5,8,8a-hexahydro-1,2,8-triacetoxy-; CAS 149913-46-2
EINECS	Contact for details

Quality Control

Every batch of (1S,2R,8R,8Ar)-1,2,8-Triacetoxy-1,2,3,5,8,8A-Hexahydro-5-Oxyindolizine is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including chiral purity verification, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.