Description

1H-Benz[De]Isoquinolin-1-One,2-(3R)-1-Azabicyclo[2.2.2]Oct-3-Yl-2,3,3A,4,5,6-Hexahydro-,(3As)- is a complex, high-purity heterocyclic compound of significant interest in advanced pharmaceutical research and development. This molecule serves as a critical chiral intermediate or building block for synthesizing novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the fields of neurology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates targeting neurological receptors.
• Research Chemical: Used in academic and industrial R&D for studying structure-activity relationships (SAR) and developing new pharmacophores.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and medicinal chemistry.
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in API manufacturing.
• Preclinical Development: Utilized in the synthesis of compounds for pharmacological screening and early-stage toxicology studies.

Basic Information

Item	Details
Product Name	1H-Benz[De]Isoquinolin-1-One,2-(3R)-1-Azabicyclo[2.2.2]Oct-3-Yl-2,3,3A,4,5,6-Hexahydro-,(3As)-
CAS No.	149654-00-2
Molecular Formula	C19H22N2O
Molecular Weight	294.39 g/mol
Synonyms	(3aS)-2-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one; (3aS)-2-((3R)-Quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one; 149654-00-2; Hexahydrobenz[de]isoquinolinone derivative; Quinuclidine-benz[de]isoquinolinone conjugate
EINECS	Contact for details

Quality Control

Our 1H-Benz[De]Isoquinolin-1-One derivative is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, chiral purity, and impurity profiles. While produced to meet exacting internal standards, specifications can be aligned with client requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.