Description

2-(tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinoline-7-Carboxylic Acid is a high-purity, protected heterocyclic carboxylic acid building block essential for advanced organic synthesis. This compound is a critical intermediate for the development of novel pharmaceuticals and bioactive molecules, offering a versatile scaffold for medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of complex drug candidates, particularly in the fields of central nervous system (CNS) and cardiovascular research.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Peptidomimetic Synthesis: Serves as a constrained amino acid analog for the creation of novel peptide-like compounds with enhanced stability and bioavailability.
• Chemical Biology Probes: Employed in the development of molecular probes and tool compounds for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Academic Research: Used in university and institutional labs for methodological development and the synthesis of novel heterocyclic compounds.

Basic Information

Product Name	2-(tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinoline-7-Carboxylic Acid
CAS No.	149353-95-7
Molecular Formula	C15H19NO4
Molecular Weight	277.32 g/mol
Synonyms	7-Carboxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 2-Boc-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid; 2-(Boc)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid; 1,2,3,4-Tetrahydro-2-[(tert-butoxy)carbonyl]-7-isoquinolinecarboxylic acid; Boc-Tic(7-COOH)-OH; tert-Butyl 7-carboxy-3,4-dihydroisoquinoline-2(1H)-carboxylate; 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydro-7-isoquinolinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 2-(tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinoline-7-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring material integrity for sensitive research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.