Description

tert-Butyl 7-Acetyl-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of complex organic molecules, particularly in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel therapeutic agents, particularly those targeting the central nervous system.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for drug discovery programs.
• Organic Synthesis Building Block: Employed in the construction of complex isoquinoline and tetrahydroisoquinoline scaffolds.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development.
• Academic Research: Utilized in university and institutional labs for methodological development and chemical biology studies.

Basic Information

Product Name	tert-Butyl 7-Acetyl-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	149353-74-2
Molecular Formula	C₁₆H₂₁NO₃
Molecular Weight	275.34 g/mol
Synonyms	7-Acetyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 7-acetyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 2(1H)-Isoquinolinecarboxylic acid, 7-acetyl-3,4-dihydro-, 1,1-dimethylethyl ester; 7-Acetyl-3,4-dihydro-2(1H)-isoquinolinecarboxylic acid tert-butyl ester; BOC-7-Acetyl-DHIQ; tert-Butyl 7-acetyl-3,4-dihydro-1H-isoquinoline-2-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Acetyl-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC chromatograms and NMR spectra, to verify identity and purity. Certificates of Analysis (COA) are available for every batch and supplied upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.