Description

(S)-n-tert-Butyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxamide is a high-purity chiral intermediate of significant importance in advanced organic synthesis. This compound is valued for its role as a key building block in the development of active pharmaceutical ingredients (APIs) and other fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for process development and scale-up.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular research.
• Asymmetric Synthesis: Used as a precursor or ligand in catalytic asymmetric reactions to induce chirality in target molecules.
• Agrochemical Research: Serves as a scaffold for developing new crop protection agents and pesticides with specific stereochemical requirements.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and enzyme functions.
• Process Chemistry: Utilized in route scouting and optimization for the commercial-scale manufacturing of complex organic molecules.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry and new reaction development.

Basic Information

Product Name	(S)-n-tert-Butyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxamide
CAS No.	149182-72-9
Molecular Formula	C₁₄H₂₀N₂O
Molecular Weight	232.32 g/mol
Synonyms	(S)-N-(tert-Butyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide; (S)-N-tert-Butyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide; (S)-TBTC; (S)-Tert-Butyl-THIQ-Carboxamide; (3S)-N-(1,1-Dimethylethyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide; (S)-1,2,3,4-Tetrahydro-N-(1,1-dimethylethyl)-3-isoquinolinecarboxamide
EINECS	Contact for details

Quality Control

Our (S)-n-tert-Butyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity. Certificates of Analysis (COA) with full traceability are provided to confirm compliance with customer specifications and support cGMP development where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.