Description

(S)-2-(Thiophen-2-Yl)-4-Phenyl-4,5-Dihydrooxazole is a high-purity chiral oxazoline derivative, a crucial building block in asymmetric synthesis and pharmaceutical research. Its value lies in its role as a versatile ligand precursor and intermediate for creating complex, optically active molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require enantiomerically pure intermediates for developing new active ingredients.

Application

• Asymmetric Catalysis: Serves as a precursor for chiral oxazoline ligands used in transition metal-catalyzed reactions like cyclopropanations, Diels-Alder reactions, and conjugate additions.
• Pharmaceutical Intermediates: A key chiral building block in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of enantiomerically pure herbicides, fungicides, and insecticides for enhanced efficacy and environmental profile.
• Material Science Research: Employed in the development of chiral polymers, liquid crystals, and advanced organic materials with specific optical properties.
• Academic & Process Chemistry: A valuable tool for method development in organic synthesis and scaling up asymmetric transformations.

Basic Information

Product Name	(S)-2-(Thiophen-2-Yl)-4-Phenyl-4,5-Dihydrooxazole
CAS No.	149065-77-0
Molecular Formula	C₁₃H₁₁NOS
Molecular Weight	229.30 g/mol
Synonyms	(S)-2-(2-Thienyl)-4-phenyl-4,5-dihydrooxazole; (S)-4-Phenyl-2-(thiophen-2-yl)-4,5-dihydro-1,3-oxazole; (S)-2-(Thiophen-2-yl)-4-phenyl-2-oxazoline; (S)-2-(2-Thienyl)-4-phenyl-2-oxazoline; (S)-4,5-Dihydro-4-phenyl-2-(2-thienyl)oxazole; (S)-Oxazole, 4,5-dihydro-4-phenyl-2-(2-thienyl)-; (S)-2-(2-Thienyl)-4-phenyl-δ⁴-oxazoline
EINECS	Contact for details

Quality Control

Our (S)-2-(Thiophen-2-Yl)-4-Phenyl-4,5-Dihydrooxazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high-purity standards required for research and development. Certificates of Analysis (COA) detailing purity, identity, and chiral purity are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.