Description

(S)-n-tert-Butyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxamide Hydrochloride is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. Its value lies in its role as a key building block for the development of active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular pathways. This compound is essential for research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, process chemistry, and method validation.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of complex drug candidates and Active Pharmaceutical Ingredients (APIs).
• Neurological Research: Used in the research and development of compounds targeting central nervous system (CNS) disorders.
• Cardiovascular Drug Development: Serves as a precursor in the synthesis of potential therapeutics for cardiovascular diseases.
• Asymmetric Synthesis: Employed as a chiral auxiliary or reagent in stereoselective chemical transformations.
• Process Chemistry & Scale-up: Utilized in route scouting, optimization, and commercial-scale manufacturing of pharmaceutical compounds.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(S)-n-tert-Butyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxamide Hydrochloride
CAS No.	149057-17-0
Molecular Formula	C₁₄H₂₁ClN₂O
Molecular Weight	268.78 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydro-N-(1,1-dimethylethyl)-3-isoquinolinecarboxamide Hydrochloride; (S)-N-tert-Butyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide Hydrochloride; (S)-TBQ Hydrochloride; (S)-TBIQ-Carboxamide HCl; (S)-3-Carbamoyl-1,2,3,4-tetrahydroisoquinoline, N-tert-butyl-, hydrochloride; (S)-N-(tert-Butyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-n-tert-Butyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxamide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.