Description

4-Hydroxy Hexenal-D3 is a deuterium-labeled analog of 4-hydroxyhexenal, a key lipid peroxidation product and advanced glycation end-product precursor. This stable isotope-labeled compound is essential for precise analytical quantification and metabolic pathway tracing in research. It is primarily used by scientists and quality control laboratories in the pharmaceutical, biotechnology, and analytical chemistry sectors for method development and validation.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference standard in LC-MS and GC-MS analysis for accurate measurement of endogenous 4-hydroxyhexenal in biological samples.
• Metabolic Pathway Tracing: Enables the study of lipid peroxidation and advanced glycation end-product (AGE) formation pathways in biochemical and pharmacological research.
• Biomarker Research: Critical for developing and validating assays to detect oxidative stress and carbonyl stress biomarkers in disease models.
• Pharmaceutical R&D: Supports drug discovery efforts targeting oxidative stress-related diseases, such as diabetes, neurodegenerative disorders, and cardiovascular conditions.
• Quality Control & Method Validation: Serves as a certified reference material (CRM) to ensure accuracy, precision, and compliance in analytical laboratories.
• Toxicology Studies: Facilitates research into the toxicological profile and metabolic fate of reactive carbonyl species.

Basic Information

Product Name	4-Hydroxy Hexenal-D3
CAS No.	148706-05-2
Molecular Formula	C6H7D3O2
Molecular Weight	117.16 g/mol
Synonyms	4-Hydroxyhexenal-d3; (E)-4-Hydroxy-2-hexenal-d3; 4-HHE-d3; 4-Oxo-2-hexenal-d3; Lipid peroxidation product-d3; HHE-d3; Deuterated 4-hydroxyhexenal; 4-Hydroxy-trans-2-hexenal-d3
EINECS	Contact for details

Quality Control

Every batch of 4-Hydroxy Hexenal-D3 is manufactured and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR and mass spectrometry to confirm structure and deuterium incorporation. Certificates of Analysis (COA) detailing batch-specific purity, isotopic enrichment, and analytical results are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and degradation. For long-term stability, keep the container in a desiccated environment. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Chemical purity)
Isotopic Purity (MS)	≥ 98 atom % D
Isotopic Enrichment	≥ 99% (D3)
Water Content (KF)	≤ 0.5%
Solvent Content (GC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.