Description

3-Bromo-1-(Triisopropylsilyl)Indole is a high-value, protected indole derivative used as a key synthetic intermediate in advanced organic chemistry. Its core value lies in the strategic combination of a reactive bromine substituent and a robust triisopropylsilyl (TIPS) protecting group, enabling precise, multi-step molecular construction. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of complex heterocyclic targets, drug candidates, and novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel indole-based drug candidates, including kinase inhibitors and serotonin receptor modulators.
• Agrochemical Synthesis: Used in the research and development of new generation herbicides and fungicides that leverage the indole scaffold for bioactivity.
• Material Science Precursor: Serves as a monomer or functional unit in the development of organic electronic materials and advanced polymers.
• Cross-Coupling Reactions: The bromine atom is an excellent site for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to introduce complex aryl or alkyl groups.
• Directed Metalation: The TIPS group directs ortho-lithiation, allowing for further functionalization of the indole ring system at specific positions.
• Chemical Biology Probes: Utilized in the creation of fluorescent tags or molecular probes for studying biological pathways and protein interactions.

Basic Information

Product Name	3-Bromo-1-(Triisopropylsilyl)Indole
CAS No.	148249-36-9
Molecular Formula	C17H26BrNSi
Molecular Weight	352.39 g/mol
Synonyms	1-Triisopropylsilyl-3-bromoindole; 3-Bromo-1-[(triisopropylsilyl)]-1H-indole; 3-Bromo-1H-indole, 1-(triisopropylsilyl)-; 3-Bromo-1-(triisopropylsilyl)-1H-indole; TIPS-3-Bromoindole; 3-Bromoindole-1-TIPS; 1-TIPS-3-bromoindole
EINECS	Contact for details

Quality Control

Our 3-Bromo-1-(Triisopropylsilyl)Indole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.