Description

1-(Hexylthio)-2-(Hexanoylamino)-1,2-Dideoxy-Sn-Glycero-3-Phosphoethanolamine is a specialized synthetic phospholipid derivative, a key building block in advanced lipid-based research and formulation. This compound is critical for developing and studying novel drug delivery systems, particularly liposomes and lipid nanoparticles, due to its unique functionalized structure. It is primarily utilized by pharmaceutical researchers, formulation scientists, and biotechnology companies focused on next-generation therapeutics and diagnostic agents.

Application

• Lipid Nanoparticle (LNP) Formulation: A critical component in the design of mRNA and siRNA delivery vehicles for gene therapy and vaccine development.
• Functionalized Liposome Production: Used to create targeted liposomes with surface-modified properties for enhanced drug delivery and cellular uptake.
• Biomembrane Research: Serves as a synthetic analog for studying membrane dynamics, protein-lipid interactions, and signal transduction pathways.
• Diagnostic Agent Carrier: Employed in the formulation of contrast agents and other diagnostic tools for medical imaging.
• Model Compound for Metabolic Studies: Used in biochemical research to investigate phospholipid metabolism and related enzymatic processes.
• Excipient Development: Explored as a novel excipient to improve the solubility, stability, and bioavailability of poorly soluble active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-(Hexylthio)-2-(Hexanoylamino)-1,2-Dideoxy-Sn-Glycero-3-Phosphoethanolamine
CAS No.	148248-15-1
Molecular Formula	C23H47N2O6PS
Molecular Weight	510.67 g/mol
Synonyms	N-Hexanoyl-1-(hexylthio)-2-amino-1,2-dideoxy-sn-glycero-3-phosphoethanolamine; 1-Hexylthio-2-hexanamido-1,2-dideoxy-sn-glycero-3-phosphoethanolamine; S-Hexyl 2-(hexanoylamino)-3-(2-hydroxyethylphosphonooxy)propyl hydrogen phosphorothioate; Phospholipid derivative 148248-15-1; Thioether-functionalized phospholipid; Custom lipid for drug delivery; Synthetic phospholipid analog
EINECS	Contact for details

Quality Control

Every batch of 1-(Hexylthio)-2-(Hexanoylamino)-1,2-Dideoxy-Sn-Glycero-3-Phosphoethanolamine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and potentially oxidizable nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.