Description

(-)-Tramadol, Hydrochloride is the pure enantiomeric form of the centrally acting analgesic, tramadol hydrochloride. This specific stereoisomer is of significant interest for advanced pharmaceutical research and development due to its distinct pharmacological profile and potential for creating more targeted therapeutic agents. It is a critical intermediate and reference standard for analytical laboratories, research institutions, and pharmaceutical companies engaged in the development of novel pain management solutions and stereoselective synthesis.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for quality control (QC) and quality assurance (QA) in the analysis of tramadol-based drug products and raw materials.
• Active Pharmaceutical Ingredient (API) Research: Serves as a key starting material or intermediate in the research and development of new enantiomerically pure analgesic formulations.
• Metabolite and Pharmacokinetic Studies: Essential for in-vitro and in-vivo studies investigating the metabolism, bioavailability, and stereoselective actions of tramadol.
• Analytical Method Development: Employed in the development and validation of chiral separation methods using techniques like HPLC and CE.
• Biochemical Research: Used to study the specific binding interactions and mechanisms of action at opioid receptors and monoamine reuptake sites.
• Impurity Profiling: Acts as a critical marker for identifying and quantifying the (-)-enantiomer as a potential impurity in racemic tramadol hydrochloride batches.

Basic Information

Product Name	(-)-Tramadol, Hydrochloride
CAS No.	148229-79-2
Molecular Formula	C16H25NO2 • HCl
Molecular Weight	299.84 g/mol (as hydrochloride salt)
Synonyms	(-)-(1R,2R)-Tramadol Hydrochloride; (1R,2R)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol Hydrochloride; Levotramadol Hydrochloride; Tramadol (-)-isomer Hydrochloride; (1R,2R)-Tramadol HCl; UNII-1J2J0F8U8F
EINECS	Contact for details

Quality Control

Our (-)-Tramadol, Hydrochloride is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and strength. We provide Certificates of Analysis (COA) with detailed results from methods including HPLC, chiral analysis, and residual solvent testing. The product is suitable for use as a pharmaceutical reference standard and in GMP-compliant research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Enantiomeric Purity (Chiral HPLC)	≥99.0% (-)-isomer
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.