Description

4-(6,7-Dimethoxy-1,2,3,4-Tetrahydro-Isoquinolin-1-Yl)-Butan-1-Ol Hydrochloride is a high-purity synthetic intermediate of significant importance in advanced pharmaceutical research and development. This compound matters as a key building block for the synthesis of complex molecules, particularly those targeting neurological and cardiovascular pathways. It is primarily needed by R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for their synthesis pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds with tetrahydroisoquinoline scaffolds.
• Neurological Research: Used in the development of potential therapeutic agents targeting receptors in the central nervous system.
• Cardiovascular Drug Development: Serves as a building block for molecules being investigated for cardiovascular applications.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale manufacturing of novel drug candidates.
• Chemical Biology & Proteomics: Can be utilized as a specialized reagent or ligand in biochemical assay development and target identification studies.
• Fine Chemical Synthesis: Acts as a versatile chiral synthon for constructing complex, polyfunctional organic molecules in academic and industrial settings.

Basic Information

Product Name	4-(6,7-Dimethoxy-1,2,3,4-Tetrahydro-Isoquinolin-1-Yl)-Butan-1-Ol Hydrochloride
CAS No.	148204-36-8
Molecular Formula	C₁₅H₂₄ClNO₃
Molecular Weight	301.81 g/mol
Synonyms	1-(4-Hydroxybutyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride; 4-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-1-yl)butan-1-ol hydrochloride; 6,7-Dimethoxy-1-(4-hydroxybutyl)-1,2,3,4-tetrahydroisoquinoline HCl; 1-(4-Hydroxybutyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline HCl; THIQ derivative 148204-36-8
EINECS	Contact for details

Quality Control

Our 4-(6,7-Dimethoxy-1,2,3,4-Tetrahydro-Isoquinolin-1-Yl)-Butan-1-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.