Description

Albuterol Dimer CAS NO 147663-30-7 is a key pharmaceutical intermediate and impurity reference standard, chemically related to the widely used bronchodilator albuterol. This compound is critical for ensuring the quality, safety, and efficacy of albuterol-based drug products by serving as a marker for degradation and process-related impurities. It is an essential material for pharmaceutical manufacturers, analytical laboratories, and regulatory bodies involved in respiratory drug development and quality control.

Application

• Primary use as a pharmaceutical reference standard for the identification and quantification of dimeric impurities in albuterol active pharmaceutical ingredients (APIs) and finished dosage forms.
• Critical component in analytical method development and validation (e.g., HPLC, UPLC) for stability-indicating assays of albuterol products.
• Essential for pharmaceutical research and development, particularly in studying degradation pathways and forced degradation studies of β-2 agonist medications.
• Used in regulatory compliance and quality assurance programs to meet pharmacopoeial requirements (USP, EP, BP) for impurity profiling.
• Serves as a synthetic intermediate in advanced chemical synthesis for novel respiratory therapeutics.
• Supports academic and industrial research into the pharmacology and stability of sympathomimetic amine drugs.

Basic Information

Product Name	Albuterol Dimer
CAS No.	147663-30-7
Molecular Formula	C26H40N2O8
Molecular Weight	508.61 g/mol
Synonyms	Salbutamol Dimer; Albuterol Dimer Impurity; 1-[3,5-Bis[(1,1-dimethylethyl)amino]-4-hydroxyphenyl]-2-(tert-butylamino)ethanol Dimer; 4-[2-(tert-Butylamino)-1-hydroxyethyl]-2-(tert-butylaminomethyl)benzene-1,3-diol Dimer; RS-Albuterol Dimer; (±)-Albuterol Dimer
EINECS	Contact for details

Quality Control

Our Albuterol Dimer is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of related substances. We provide full traceability and Certificates of Analysis (COA) that detail all test results against established specifications, supporting compliance with cGMP and ICH guidelines for pharmaceutical impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.