Description

Ontazolast is a potent and selective leukotriene D4 (LTD4) receptor antagonist, representing a significant class of therapeutic agents targeting inflammatory pathways. Its primary value lies in its ability to modulate allergic and inflammatory responses, making it a critical intermediate in advanced pharmaceutical research and development. This compound is essential for researchers and manufacturers in the pharmaceutical industry focused on developing novel treatments for asthma, allergic rhinitis, and other inflammatory conditions.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced anti-inflammatory and anti-asthmatic drug candidates.
• Biochemical Research: Used as a reference standard and tool compound in pharmacological studies of leukotriene receptors and signal transduction pathways.
• Drug Discovery & Development: Serves as a core scaffold for structure-activity relationship (SAR) studies aimed at optimizing potency and selectivity of LTD4 antagonists.
• Preclinical Studies: Employed in in vitro and in vivo models to investigate the efficacy and mechanism of action of leukotriene-modulating therapies.

Basic Information

Product Name	Ontazolast
CAS No.	147432-77-7
Molecular Formula	C23H21N3O4S
Molecular Weight	435.50 g/mol
Synonyms	Ontazolast; BAY-x-1005; BAY x 1005; BAYx1005; 4-[(5-Chloro-2,3-dihydro-2-hydroxy-1-oxo-1H-inden-5-yl)oxy]phenyl methyl sulfoxide; 5-[[4-[(Methylsulfinyl)phenyl]oxy]-5-chloro-2,3-dihydro-2-hydroxy-1H-inden-1-one; LTD4 receptor antagonist BAY-x-1005.
EINECS	Contact for details

Quality Control

Our Ontazolast is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development purposes. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.