Description

(Z)-Methyl 2-Ethoxy-3-((2'-(N'-Hydroxycarbamimidoyl)Biphenyl-4-Yl)Methyl)-3H-Benzo[D] Imidazole-4-Carboxylate is a high-purity, non-peptidic chemical intermediate of significant interest in advanced pharmaceutical research and development. Its complex molecular architecture, featuring a benzimidazole core linked to a biphenyl moiety, makes it a critical building block for synthesizing novel therapeutic agents. This compound is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates targeting specific enzyme pathways.
• Protease Inhibitor Research: Used in the development of potential inhibitors for enzymes like thrombin or factor Xa, relevant in anticoagulant therapy.
• Chemical Biology Probe: Serves as a scaffold for creating molecular probes to study protein function and biological mechanisms.
• Medicinal Chemistry Optimization: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• GMP Manufacturing: Supplied as a starting material or advanced intermediate for cGMP production of active pharmaceutical ingredients (APIs).
• Contract Research & Development: Essential for CROs and CDMOs engaged in custom synthesis and process development for client projects.

Basic Information

Product Name	(Z)-Methyl 2-Ethoxy-3-((2'-(N'-Hydroxycarbamimidoyl)Biphenyl-4-Yl)Methyl)-3H-Benzo[D] Imidazole-4-Carboxylate
CAS No.	147403-65-4
Molecular Formula	C27H26N4O4
Molecular Weight	470.52 g/mol
Synonyms	Methyl 2-ethoxy-3-{[2'-(N-hydroxycarbamimidoyl)biphenyl-4-yl]methyl}-3H-benzimidazole-4-carboxylate; (Z)-Isomer of Biphenylmethyl Benzimidazole Carboxylate; L-371,912 (historical research code); DU-176b analog intermediate; Thrombin inhibitor intermediate; Biphenyl amidoxime derivative; Non-peptidic benzimidazole intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to stringent quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications for assay, related substances, residual solvents, and other critical parameters. We support development and commercial projects with material suitable for GMP manufacturing upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Long-term storage under inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0% (Area Percent)
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Individual impurity ≤1.0%; Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.