Description

3-Ethyl-D5-Adenine is a stable isotope-labeled analog of adenine, a fundamental purine base. This deuterated compound is essential for advanced analytical and research applications where precise molecular tracking is required. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications such as mass spectrometry and metabolic studies.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in bioanalytical methods for drug metabolism and pharmacokinetic (DMPK) studies.
• Metabolic Pathway Tracing: Used in deuterium labeling experiments to investigate the metabolic fate of adenine derivatives and related nucleobases.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities or degradation products in active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed as a tool in enzymatic studies and receptor binding assays to understand biological mechanisms without isotopic interference.
• Stable Isotope-Labeled Reference Material: Provides a benchmark for quality control and method validation in analytical laboratories.

Basic Information

Product Name	3-Ethyl-D5-Adenine
CAS No.	147028-85-1
Molecular Formula	C7D5H4N5
Molecular Weight	179.20 g/mol
Synonyms	3-Ethyladenine-d5; 3-EA-d5; Adenine-3-ethyl-d5; 9H-Purin-6-amine, 3-ethyl-d5; Deuterated 3-Ethyladenine; 3-Ethyl-1,2,7,8,9-D5-adenine; 3-Ethyl-adenine (pentadeutero)
EINECS	Contact for details

Quality Control

Our 3-Ethyl-D5-Adenine is manufactured under controlled conditions to ensure high isotopic purity and chemical integrity. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm deuterium incorporation and chemical purity. A comprehensive Certificate of Analysis (COA) detailing isotopic purity (e.g., D5 > 98%), chemical purity (by HPLC), and other critical parameters is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D5)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.