Description

Moxilubant is a selective and potent antagonist of the leukotriene B4 (LTB4) receptor, BLT1. This compound is a critical research tool for investigating inflammatory pathways and has significant potential in the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on respiratory diseases, dermatological conditions, and other inflammation-mediated disorders.

Application

• Pharmacological Research: A key reference standard and active agent in studies targeting the LTB4-BLT1 signaling pathway for anti-inflammatory drug discovery.
• Inflammation Model Development: Used to establish and validate in vitro and in vivo models of diseases such as asthma, psoriasis, and rheumatoid arthritis.
• Biochemical Assays: Employed in high-throughput screening (HTS) and binding assays to identify and characterize new BLT1 receptor modulators.
• Mechanism of Action Studies: Essential for elucidating the role of LTB4 in neutrophil chemotaxis, degranulation, and other immune cell functions.
• Preclinical Development: Serves as a lead compound or comparator in the preclinical evaluation of novel anti-inflammatory candidates.

Basic Information

Product Name	Moxilubant
CAS No.	146978-48-5
Molecular Formula	C₂₀H₂₀N₂O₃S
Molecular Weight	368.45 g/mol
Synonyms	BIIL 284; BIIL-284; BIIL284; (R)-2-(4-Chlorobenzyl)-1-[(2,4-difluorophenyl)sulfonyl]-1,2,3,4-tetrahydro-7-methoxyisoquinoline-3-carboxylic Acid; 1-[(2,4-Difluorophenyl)sulfonyl]-N-[(4-methoxyphenyl)methyl]-L-tryptophan; L-Tryptophan, 1-[(2,4-difluorophenyl)sulfonyl]-N-[(4-methoxyphenyl)methyl]-
EINECS	Contact for details

Quality Control

Our Moxilubant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be kept in a desiccated environment. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.