Description

{[3-(Trifluoromethyl)Phenyl]Methyl}Phosphonic Acid is a high-value organophosphorus compound featuring a trifluoromethylphenyl group, making it a versatile building block in advanced chemical synthesis. Its unique structure provides a combination of lipophilicity and electronic effects, which is critical for developing compounds with tailored properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for creating active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of novel active pharmaceutical ingredients (APIs), especially for targets requiring enhanced membrane permeability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators where the phosphonic acid moiety and fluorine atoms contribute to biological activity.
• Ligand and Catalyst Preparation: Acts as a precursor for phosphonate-based ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of flame retardants, corrosion inhibitors, and specialty polymers where phosphorus-containing groups add functionality.
• Chemical Research: A valuable reagent in organic and medicinal chemistry for constructing complex molecules, particularly in cross-coupling reactions and as a bioisostere.

Basic Information

Product Name	{[3-(Trifluoromethyl)Phenyl]Methyl}Phosphonic Acid
CAS No.	146780-09-8
Molecular Formula	C8H8F3O3P
Molecular Weight	240.12 g/mol
Synonyms	(3-Trifluoromethylbenzyl)phosphonic Acid; [3-(Trifluoromethyl)benzyl]phosphonic Acid; α-(Trifluoromethyl)benzylphosphonic Acid; (3-(Trifluoromethyl)phenyl)methylphosphonic Acid; Phosphonic acid, P-[[3-(trifluoromethyl)phenyl]methyl]-; m-Trifluoromethylbenzylphosphonic Acid
EINECS	Contact for details

Quality Control

Our production of {[3-(Trifluoromethyl)Phenyl]Methyl}Phosphonic Acid adheres to stringent quality management protocols. Every batch is analyzed using advanced techniques like HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems are designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.