Description

Dl-(2-Amino-2-Carboxyethyl)-Homocysteine-3,3,4,4-D4 is a deuterium-labeled isotopologue of the sulfur-containing amino acid derivative, homocysteine. This compound is of significant value as a stable isotope-labeled internal standard for precise quantitative analysis in mass spectrometry-based applications. It is primarily required by research institutions, pharmaceutical companies, and clinical diagnostic laboratories engaged in metabolomics, biomarker discovery, and pharmacokinetic studies where accurate measurement of homocysteine and related metabolites is critical.

Application

• Mass Spectrometry Internal Standard: Serves as a critical reference compound for the accurate quantification of homocysteine in LC-MS/MS and GC-MS assays, correcting for instrument variability and matrix effects.
• Biomedical Research: Used in tracer studies to investigate the methionine cycle, homocysteine metabolism, and related pathways in cellular and animal models.
• Clinical Diagnostics: Enables the development and validation of high-precision diagnostic tests for conditions like hyperhomocysteinemia, which is linked to cardiovascular and neurological disorders.
• Pharmaceutical Development: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug candidates that interact with sulfur amino acid pathways.
• Nutraceutical & Food Science: Facilitates research into the bioavailability and metabolic effects of B-vitamins (e.g., B6, B12, folate) that regulate homocysteine levels.
• Metabolomics Profiling: A key component in targeted metabolomics panels for comprehensive analysis of amino acid and one-carbon metabolism.

Basic Information

Product Name	Dl-(2-Amino-2-Carboxyethyl)-Homocysteine-3,3,4,4-D4
CAS No.	146764-57-0
Molecular Formula	C7H10D4N2O4S
Molecular Weight	210.28 g/mol (for deuterated form)
Synonyms	Homocysteine-d4 (3,3,4,4-D4); DL-Homocysteine-3,3,4,4-d4; 2-Amino-4-[(2-amino-2-carboxyethyl)sulfanyl]butanoic-3,3,4,4-d4 acid; Deuterated Homocysteine; L-Homocysteine-d4; Isotopically Labeled Homocysteine; S-(2-Amino-2-carboxyethyl)-L-homocysteine-d4; Internal Standard for Homocysteine Assay
EINECS	Contact for details

Quality Control

Every batch of Dl-(2-Amino-2-Carboxyethyl)-Homocysteine-3,3,4,4-D4 is produced and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive testing to ensure suitability as an internal standard. Certificates of Analysis (COA) are provided with each shipment, detailing parameters such as assay, isotopic enrichment, and purity by HPLC and NMR. Our quality commitment aligns with the needs of research and regulated laboratory environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive); therefore, containers should be allowed to equilibrate to room temperature before opening to minimize moisture ingress. Store in a cool, dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.