Description

Bicyclo[2.2.1]Heptan-7-One, 2-Ethynyl-, (1R,2R,4S)-Rel- (9Ci) is a high-purity, stereochemically defined bicyclic ketone derivative featuring an ethynyl substituent, making it a valuable chiral building block for advanced organic synthesis. Its rigid, functionalized norbornane-like structure is critical for constructing complex molecular architectures with precise three-dimensional control. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate in the development of active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly in antiviral, anti-inflammatory, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its rigid scaffold for bioactive molecule design.
• Advanced Material Precursor: Serves as a building block for specialty polymers, liquid crystals, and other functional materials requiring specific stereochemistry.
• Asymmetric Catalysis Ligand Synthesis: Employed in the preparation of novel chiral ligands and organocatalysts for enantioselective transformations.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry, including cycloaddition reactions and ring-opening polymerizations.
• Flavor & Fragrance Intermediate: Potential use in the synthesis of high-value odorants and flavoring agents with unique olfactory properties.

Basic Information

Product Name	Bicyclo[2.2.1]Heptan-7-One, 2-Ethynyl-, (1R,2R,4S)-Rel- (9Ci)
CAS No.	146680-86-6
Molecular Formula	C9H10O
Molecular Weight	134.18 g/mol
Synonyms	(1R,2R,4S)-2-Ethynylbicyclo[2.2.1]heptan-7-one; rel-(1R,2R,4S)-2-Ethynyl-2-norbornanone; 2-Ethynyl-2-norbornanone, (1R,2R,4S)-rel-; 2-Ethynylnorbornan-7-one; Bicyclo[2.2.1]heptan-7-one, 2-ethynyl-, (1R,2R,4S)-rel-; 146680-86-6; (1R,2R,4S)-rel-2-Ethynylbicyclo[2.2.1]heptan-7-one
EINECS	Contact for details

Quality Control

Our Bicyclo[2.2.1]Heptan-7-One, 2-Ethynyl-, (1R,2R,4S)-Rel- (9Ci) is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We support compliance with relevant regulatory frameworks, including REACH and FDA guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.