Description

4-Hydroxybenzoic Acid-α-13C is a stable isotope-labeled analog of 4-hydroxybenzoic acid, where the carbon atom at the alpha position is enriched with the Carbon-13 isotope. This compound is essential as an internal standard and tracer in advanced analytical and metabolic research, providing unparalleled accuracy for quantitative mass spectrometry. It is primarily required by researchers and manufacturers in the pharmaceutical, agrochemical, and life science sectors for drug metabolism studies (DMPK), proteomics, and the development of stable isotope dilution assays (SIDA).

Application

• Internal Standard for Quantitative Analysis: Used as a critical reference standard in LC-MS and GC-MS for the precise quantification of 4-hydroxybenzoic acid and related metabolites in complex biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as a stable isotope tracer to study the absorption, distribution, metabolism, and excretion (ADME) pathways of pharmaceutical compounds.
• Proteomics and Metabolomics Research: Enables accurate relative and absolute quantification in high-throughput profiling studies to discover biomarkers and understand biochemical pathways.
• Agrochemical Research: Applied in environmental fate studies and residue analysis of pesticides and herbicides where parabens or their breakdown products are monitored.
• Food and Flavor Analysis: Utilized in stable isotope dilution assays to accurately measure parabens or benzoic acid derivatives used as preservatives in food and beverage products.
• Synthesis of Labeled Compounds: Acts as a key building block for the synthesis of more complex Carbon-13 labeled molecules for research and diagnostic purposes.

Basic Information

Product Name	4-Hydroxybenzoic Acid-α-13C
CAS No.	146672-02-8
Molecular Formula	C7H6O3 (with 13C at alpha position)
Molecular Weight	~139.12 g/mol (exact mass depends on 13C enrichment)
Synonyms	p-Hydroxybenzoic Acid-α-13C; 4-Hydroxybenzoic-α-13C Acid; Benzoic-α-13C acid, 4-hydroxy-; p-Hydroxybenzoic Acid (α-13C); 4-Hydroxybenzoic Acid (Carbon-13 Labeled); [α-13C]-4-Hydroxybenzoic Acid; 13C Labeled Paraben Precursor
EINECS	Contact for details

Quality Control

Our 4-Hydroxybenzoic Acid-α-13C is manufactured under controlled conditions to ensure the highest isotopic and chemical purity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (atom % 13C), chemical purity by HPLC, and identification by spectroscopic methods. We adhere to stringent quality protocols suitable for research and analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (Atom % 13C)	≥ 99% (Typical)
Chemical Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.