Description

3-[2[[(1,1-Dimethylethyl)Dimethyl Silyl]Oxy]Ethyl]-Piperidine is a specialized organosilicon-protected piperidine derivative, a crucial building block in advanced organic synthesis. Its primary value lies in its role as a key protected intermediate, enabling the selective manipulation of amine functionality in complex molecule construction. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of complex drug molecules, particularly those containing piperidine or substituted amine pharmacophores.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where the protected amine group is required for selective reactions.
• Organic Synthesis Reagent: Serves as a versatile synthon in academic and industrial research for constructing nitrogen-containing heterocycles and complex natural product analogs.
• Peptidomimetics Development: Employed in the design and synthesis of peptide mimics where the tert-butyldimethylsilyl (TBDMS) protected aminoethyl side chain is incorporated.
• Ligand and Catalyst Preparation: Acts as a precursor for nitrogen-containing ligands used in asymmetric catalysis and metal complex formation.

Basic Information

Product Name	3-[2[[(1,1-Dimethylethyl)Dimethyl Silyl]Oxy]Ethyl]-Piperidine
CAS No.	146667-82-5
Molecular Formula	C13H29NOSi
Molecular Weight	243.46 g/mol
Synonyms	3-[2-[(tert-Butyldimethylsilyl)oxy]ethyl]piperidine; 1-(2-{[tert-Butyl(dimethyl)silyl]oxy}ethyl)piperidin-3-amine; N-(tert-Butyldimethylsilyloxyethyl)-3-piperidinamine; 3-(2-((tert-Butyldimethylsilyl)oxy)ethyl)piperidine; TBDMS-protected 3-(2-hydroxyethyl)piperidine; 3-(2-Hydroxyethyl)piperidine TBDMS ether; tert-Butyldimethyl[2-(3-piperidinyl)ethoxy]silane
EINECS	Contact for details

Quality Control

Our 3-[2[[(1,1-Dimethylethyl)Dimethyl Silyl]Oxy]Ethyl]-Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity assessment and identity confirmation, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.