Description

Mal-Peg3-Alcohol CAS NO 146551-23-7 is a heterobifunctional polyethylene glycol (PEG) linker featuring a maleimide group at one terminus and a hydroxyl group at the other, separated by a triethylene glycol spacer. This compound is a critical reagent in bioconjugation chemistry, enabling the site-specific attachment of biomolecules, such as antibodies or peptides, to various payloads, surfaces, or other functional groups. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries for developing advanced therapeutics, including antibody-drug conjugates (ADCs), and for surface functionalization.

Application

• Antibody-Drug Conjugate (ADC) Development: The maleimide group selectively reacts with thiol groups on cysteine residues of antibodies, while the hydroxyl group can be further functionalized to attach cytotoxic drugs or labels.
• PEGylation of Biomolecules: Used to introduce a hydrophilic PEG spacer onto proteins, peptides, or other active molecules to improve solubility, stability, and circulation half-life.
• Surface Functionalization: The hydroxyl terminus can be used to covalently anchor the linker to surfaces (e.g., glass, gold, polymers) for creating biosensor chips or assay platforms, with the maleimide group available for capturing thiol-containing probes.
• Crosslinking Reagent: Facilitates the conjugation between two different molecules, one containing a thiol and the other a group reactive with a hydroxyl (after activation), for creating defined bioconjugates.
• Diagnostic Reagent Synthesis: Employed in the construction of immunoassay components by linking detection enzymes or fluorescent dyes to antibodies or antigens.
• Polymer Chemistry: Serves as a functional monomer or macromonomer for synthesizing advanced polymeric materials with tailored bioreactive properties.

Basic Information

Product Name	Mal-Peg3-Alcohol
CAS No.	146551-23-7
Molecular Formula	C15H25NO7
Molecular Weight	331.36 g/mol
Synonyms	3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propyl 2-[2-(2-hydroxyethoxy)ethoxy]ethyl ether; Maleimide-PEG3-alcohol; 1-(3-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)propyl)-1H-pyrrole-2,5-dione; Mal-PEG3-OH; Maleimide-PEG3-OH; mPEG3-Mal; Heterobifunctional PEG linker Mal-PEG3-OH; N-(3-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)propyl)maleimide
EINECS	Contact for details

Quality Control

Our Mal-Peg3-Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.