Description

Benzyl (3R)-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylate is a high-purity chiral building block of significant importance in advanced organic synthesis. This compound matters because it serves as a key intermediate for constructing complex molecules with specific stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs). It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel therapeutic agents and specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Asymmetric Synthesis: Used as a starting material or reagent in stereoselective reactions to introduce the (3R)-tetrahydroisoquinoline moiety into target molecules.
• Agrochemical Research: Employed in the synthesis of novel, optically active pesticides and herbicides where specific chirality impacts biological activity.
• Catalyst and Ligand Development: Serves as a precursor for creating novel chiral catalysts and ligands used in homogeneous catalysis.
• Academic & Contract Research: Utilized in university laboratories and CROs (Contract Research Organizations) for methodological studies and custom synthesis projects.
• Fine Chemical Production: Integral in the multi-step synthesis of complex, high-value specialty chemicals and flavors/fragrances.

Basic Information

Product Name	Benzyl (3R)-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylate
CAS No.	146503-35-7
Molecular Formula	C17H17NO2
Molecular Weight	267.32 g/mol
Synonyms	(R)-Benzyl 1,2,3,4-Tetrahydro-3-isoquinolinecarboxylate; (3R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic Acid Benzyl Ester; Benzyl (R)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylate; (R)-Benzyl 3,4-Dihydro-1H-isoquinoline-3-carboxylate; (R)-Benzyl THIQ-3-carboxylate; (R)-Benzyl Tic-OBzl; (R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic Acid, Benzyl Ester
EINECS	Contact for details

Quality Control

Our Benzyl (3R)-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for research and development use. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.